Metabolism Made Easy

This podcast covers the details of the conversion of lactate produced during exercise to glucose in the liver and ultimately releasing it to the bloodstream.

This pocast covers the regulation of the Rate-limiting enzyme in fatty acid synthesis, Acetyl CoA Carboxylase allosterically, and by covalent modification.

This podcast covers the regulation of HMG CoA Reductase by hormones, covalent modification, cytoplasmic cholesterol, and statins.

This podcast defines metabolism and its two distinct components: anabolism and catabolism. The major compartments involved in both are also covered. If you like this podcast, feel free to donate to the podcast.

This podcast covers the distinct uses of glucose, fatty acids, and amino acids and their unique roles in metabolism.

This podcast covers the key role of the liver and adipose tissue in providing energy sources to the plasma during fasting. The liver is the provider of glucose and fatty acids, while adipose tissue provides fatty acids to the bloodstream.

While following a ketogenic diet, maintenance of plasma glucose is essential for several tissues. The amino acids derived from dietary proteins will provide the carbon skeletons for glucose synthesis by the liver, while the triacylglycerols from dietary fat will provide the energy for various tissues through Beta-oxidation of fatty acids.

This podcast covers the production of cAMP by activation of either the beta-adrenergic receptor or the glucagon receptor as well as the activation of the alpha1-adrenergic by epinephrine to produce IP3, DG and calcium.

This podcast covers the major pathways for catabolism of glucose and fatty acids, including the ATP output from their complete degradation to CO2. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the target enzymes of NSAIDS and cortisol and their respective effects on inflammation. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the effect of phophorylstion/dephosphorylation by protein kinases and phosphatases on enzyme activity. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the activation of the Insulin receptor resulting in activation of an intracellular protein phosphatase. The deposphorylation of eight enzymes is also covered. This dephosphorylation results in profound effects on carbohydrate, lipid and protein metabolism. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the key tissue effects of insulin in the well-fed state including its effects on liver, muscle and adipose tissue. Also covered are the effects of insulin on regulating key enzymes involved in carbohydrate and lipid metabolism.

Similar content is available at:
MEDBIOCHEM.ORG

This podcast describes the digestion, reassembly, absorption and storage of dietary Triacylglycerol including the role of pancreatic lipase and lipoprotein lipase. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the liver output of glucose during fasting and its regulation by glucagon. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the phosphorylation of enzymes by protein kinases that modify specific hydroxyl residues in enzymes. This content may be useful to premedical and medical students. Similar biochemistry content is available at: MEDBIOCHEM.ORG

This podcast describes the specific mechanism by which statins reduce plasma cholesterol. The reduction of cholesterol synthesis by statins in effect, will result in the upregulation of the LDL receptor and increased uptake of LDL from plasma. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the specific metabolic effects of insulin on liver, muscle and adipose tissue. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the key components of the adenylate cyclase system including receptor activation, G-protein involved, activation of adenylate cyclase , production of cAMP, activation of PKA and termination of the actions of cAMP . Also included is a historical perspective of the discovery of G-proteins the adeylate cyclase system.

This podcast describes the effect of cortisol on eicosanoid biosynthesis and its resulting anti-inflammatory effects. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the only 2 enzymes that require Vitamin B12 . This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the 4 enzymes requiring thiamine as a coenzyme. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the carbon skeletons derived from amino acids and their classification as glucogenic or ketogenic. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the major sources of NADPH and its primary uses in 5 biological reactions. This content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the regulation of acetyl CoA Carboxylase allosterically and by covalent modification. The effect of malonyl CoA on beta oxidation of fatty acids is also described. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the molecules that can produce acetyl CoA as well as the possible metabolic fates of acetyl CoA. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast is an overview of the components of metabolism, namely, catabolism and anabolism and their respective cellular functions. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the purine salvage pathway and the inherited deficiency in the salvage of hypoxanthine and guanine (HGPRT) and its outcome in infants. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG.

This podcast covers the mutual regulation of glycolysis and gluconeogenesis by allosteric regulators, thus preventing the likelihood of a futile cycle from occurring. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the underlying changes associated with insulin resistance and resulting in dyslipidemia. These changes include effects on two key lipases namely, Lipoprotein Lipase and Hormone-Sensitive Lipase. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes one of the key outcomes of insulin resistance, hyperglycemia, including the specific tissue contributions to the rise in plasma glucose. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the underlying changes associated with insulin resistance and its consequences in both plasma and target tissues. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast is a summary of the biosynthesis of non-essential amino acids from their respective carbon skeletons. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the signals for insulin secretion by the pancreas and the molecular mechanism behind its secretion by the islets of Langerhans beta cells. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the role of cytosolic citrate in regulating glycolysis, fatty acid synthesis and providing thd vehicle to transport Acetyl CoA to the cytoplasm where it is needed for lipid synthesis. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the fifth unique liver function in its ability to detoxify organic molecules by making them more water soluble. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the role of the Urea cycle in detoxifying ammonia as the fifth unique function of the liver. This biochemistry content may be useful to premedical and medical students.Similar content is available at:MEDBIOCHEM.ORG

This podcast describes the second unique role of the liver in cholesterol biosynthesis, storage and uptake of LDL from plasma. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG Check out my YouTube playlist:https://youtube.com/playlist?list=PLXy2KYiCd9rlg0JmfA392WrEiOYNu39xn

This podcast describes the unique function of the liver in producing glucose during fasting. The liver restores blood glucose through two coordinated processes, glycogenolysis and gluconeogenesis. The podcast also covers the key regulation of both processes by glucagon/epinephrine. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers 5 unique functions that are either exclusive to the liver, or occur mostly in the liver. These functions include: glucose production, cholesterol synthesis, ketone bodies synthesis, the Urea cycle and detoxification of organic molecules. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers 3 key features of Lipoprotein Lipase including its location, unique function and upregulation by insulin. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the mechanism of action of Statins and how they are able to reduce plasma cholesterol. This biochemistry content may be useful to premedical and medical students.

This podcast describes the role of glutamine in detoxifying ammonia produced in peripheral tissues and its transport in the bloodstream for further metabolism and/or disposal of ammonia. This biochemistry content may be useful to premedical and medical students. Similar content is available at:MEDBIOCHEM.ORG

This podcast describes the sources of nitrogen that enter the Urea cycle including the role of 3 enzymes (ALT, AST, GDH) in collecting nitrogen from amino acid metabolism. The role of Glutamate as a sink for nitrogen is also covered. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG or YouTube channel: Metabolism Made Easy.

This podcast describes some of the key features of the essential amino acid methionine, as well as, the role of vitamin B12 and folic acid in its resynthesis from homocysteine. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast defines and describes the use of ketogenic and glucogenic carbon skeletons derived from amino acids. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG or Check out my YouTube channel: Metabolism Made Easy.

This podcasts explains why glucose cannot be made from fatty acid beta oxidation products i.e. Acetyl CoA. Exceptions to this concept are also included. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes protein degradation and some of the signals that target cellular proteins for proteolysis. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes 4 types of important lipases with unique locations and functions. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the strategy of targeting 3 enzymes in nucleotide biosynthesis by chemotherapy drugs. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the composition, digestion and reassembly of triacylglycerol from the diet. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast provides a simple approach for creating and organizing an effective in class or online presentation.

This podcast describes the key metabolic effects of insulin and glucagon in various tissues. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the basics of writing and organizing a research grant proposal in the life sciences.

This podcast describes the synthesis of eicosanoids from arachidonic acid as well as their key roles in inflammation. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the synthesis of leukotrienes from arachidonic acid and their role in hypersensitivity reactions. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the two different eicosanoids derived from linoleic acid and linolenic acid, respectively and their relative effects in in the inflammatory response. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the two major eicosanoids prostacyclin and thromboxzne A2 and their role in the maintenance of vascular health. The role of Aspirin in vascular health is also covered. This biochemistry content may be useful to premedical and medical students.

This podcast covers the regulation of HMG CoA reductase by hormones, cholesterol and statins. This biochemistry content may be useful to premedical and medical students.

This podcast summarizes the steps of cholesterol biosynthesis starting with acetyl CoA as the precursor. This biochemistry content may be useful to premedical and medical students.

This podcast summarizes the key features about cholesterol including dietary intake, biosynthesis and key roles in normal cellular and tissue functions. This biochemistry content may be useful to premedical and medical students.

This podcast covers 5 key questions to ask that will help students organize intermediary metabolic pathways. This biochemistry content may be useful to premedical and medical students.

This podcast covers the two signals that terminate the effects of cAMP following receptor activation. This biochemistry content may be useful to premedical and medical students.

This podcast defines the term, fat and addresses 5 myths about our understanding and perception of fat in the diet. This biochemistry content may be useful to premedical and medical students.

This podcast summarizes the key metabolic effects of Insulin and Glucagon in various tissues. This biochemistry content may be useful to premedical and medical students.

This podcast covers 5 important questions to ask about glycolysis that could be helpful in organizing the pathway (and other pathways), while focusing on key information about the pathway. This biochemistry content may be useful to premedical and medical students.

This podcast covers the inhibitors, uncouplers, adnenine nucleotide translocase inhibitors, the effect of hypoxia, as well as the regulation of the Electron Transport Chain. This biochemistry content may be useful to premedical and medical students.

This podcast covers the complexes of the Electron Transport Chain, the flow of electrons, the enzymes involved and the synthesis of ATP at complex V. This biochemistry content may be useful to premedical and medical students.

This episode covers the role of the Electron Transport Chain in coverting high energy molecules into usable energy in the form of ATP. This biochemistry content may be useful to premedical and medical students.

This podcasts covers the 4 possible fates of pyruvate. This biochemistry content may be useful to premedical and medical students.

This podcast covers the total energy output from glycolysis, pyruvate dehydrogenase and the TCA cycle starting with glucose. This biochemistry content may be useful to premedical and medical students.

This podcast covers the regulation of the cycle and other key regulatory roles of citrate. This biochemistry content may be useful to premedical and medical students.

This podcast covers the enzymes in the TCA cycle and its energy output. This biochemistry content may be useful to premedical and medical students.

This podcasts covers the major fuel stores (reserves) available during fasting. This biochemistry content may be useful to premedical and medical students.

This podcast covers lactate dehydrogenase and lactic acidosis. This biochemistry content may be useful to premedical and medical students.

This podcast covers pyruvate dehydrogenase deficiency and thiamine deficiency clinical outcomes. This biochemistry content may be useful to premedical and medical students.

This episode covers pyruvate dehydrogenase, coenzyme requirements and its regulation in detail. This biochemistry content may be useful to premedical and medical students.

This podcast covers the regulation of the Urea cycle, the detoxification of ammonia in peripheral tissues as well as some important clinical correlates. This biochemistry content may be useful to premedical and medical students.

This podcast covers the steps in the Urea cycles including the sources of nitrogens that enter the cycle. This biochemistry content may be useful to premedical and medical students.

This episode covers the regulation of pyruvate kinase and the effect of enzyme deficiency on red blood cells. This biochemistry content may be useful to premedical and medical students.

This podcast describes the activation of the alpha1-adrenergic receptor and the production of the second messengers DAG, IP3 and calcium. This biochemistry content may be useful to premedical and medical students.

This podcast describes the activation of the beta-adrenergic receptor and the generation of the second messenger, cAMP in detail. This biochemistry content may be useful to premedical and medical students.

This podcast provides an overview of G-protein coupled recertors (GPCRs) and Second messengers. This biochemistry content may be useful to premedical and medical students.

This podcast describes the activation of receptors tyrosine kinase receptors. This biochemistry content may be useful to medical and premedical students.

This podcast describes the mechanism of action of steroid receptors and the types of cellular responses they ellicit. This biochemistry content may be useful to premedical and medical students.

This podcast describes the 4 types of receptors involved in cellular signaling. This biochemistry content may be useful to premedical and medical students.

This podcasts describes the various types of enzyme inhibition with some specific examples. This biochemistry content may be useful to premedical and medical students.

This podcast summarizes the major types of enzyme regulatory mechanisms. This biochemistry content may be useful to premedical and medical students.

This podcasts covers the major reactions where tetrahydrofolate and B 12 are needed. This biochemistry content may be useful to premedical and medical students.

This podcast describes the packaging and disposal of ammonia. This biochemistry content may be useful to premedical and medical students.

This podcast describes the glutamate dehydrogenase reaction and its regulation. This biochemistry content may be useful to premedical and medical students.

This podcast describes the effect of alcohol metabolism on depleting important gluconeogenic intermediates, namely, pyruvate, oxaloacetate and Glyceradehye 3-P by a rise in NADH. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the reaction details and regulation of the aminotransferases ALT and AST. This biochemistry content may be useful to premedical and medical students.

This podcast provides an overview of protein digestion in the small intestine including the mechanism of activation of zymogens. An introduction to transaminases is also covered. This biochemistry content may be useful to premedical and medical students.

This podcast describes the major nutrients in the diet and their overall catabolism to produce energy. This biochemistry content may be useful to premedical and medical students.

This podcast describes the latter steps of gluconeogenesis and covers the key regulatory molecules of the pathway. This biochemistry content may be useful to premedical and medical students.

This podcasts covers the key bypass steps in gluconeogenesis and their regulation (part I). This biochemistry content may be useful to premedical and medical students.

This podcast describes the biosyhthesis of pyrimidenes and summarizes some of the cancer therapeutic strategies targeting nucleotide biosynthesis. This biochemistry content may be useful to premedical and medical students.

This podcasts describes some of the key features of purine biosynthesis including important therapeutic strategies for disrupting nucleotide synthesis. This biochemistry content may be useful to premedical and medical students.

This podcast describes the key metabolic changes in various organs during the fasting state. This biochemistry content may be useful to premedical and medical students.

This podcast describes the major metabolic changes associated with the various organs during the well-fed state. This biochemistry content may be useful for premedical and medical students.

This podcast covers the last 6 steps in glycolysis from Aldolase A to Lactate dehydrogenase. Key regulation of the entire pathway is also covered. This biochemistry content may be useful to premed and medical students.

This podcast describes the regulation of phosphofructokinase-1 (PFK1) in some detail and its allosteric activation by fructose 2, 6 -bis- phosphate. This biochemistry content might be useful to premedical and medical students.

This podcast describes the first step in glycolysis and covers the properties of the two isozymes hexokinase and glucokinase in some detail. This biochemistry content might be useful to premedical and medical students.

This podcast presents an overview of glycolysis including some tissue specific aspects of the pathway. This biochemistry content may be useful for premed and medical students.

This podcast describes the key features and tissue distribution of the various types of glucose transporters. This biochemistry content may be useful to premed and medical students.

This podcast describes the metabolic processes responsible for maintenance of normal glucose levels in the plasma. This biochemistry content may be useful to premed and medical students.

This podcast covers thd mechanism of activation of two GPCRs: The beta- adrenergic and the alpha1-adrenergic receptors. This biochemistry content may be useful to premedical and medical students.

This podcast covers the four major classes of receptors and their mechanism of activation to generate a cellular response. This biochemistry content may be useful to premedical and medical students.

This podcast describes the activation of the glucagon receptor and some of its key metabolic effects. This biochemistry content may be useful to premedical and medical students.

This podcast summarizes the key metabolic effects of glucagon. This biochemistry content may be useful to premedical and medical students.

This podcast describes the major metabolic effects of insulin in various tissues. This biochemistry content may be useful to premedical and medical students.

This podcast describes the activation of the Insulin receptor and some of the cellular responses associated with insulin binding to its receptor.

This podcast briefly describes the synthesis and function of ketone bodies.

The podcast describes the secretion and synthesis of insulin by the pancreas.