Metabolism Made Easy

This podcast provides an overview of metabolic changes associated with fasting, including key metabolic changes in the liver and adipose tissue. The liver will increase its output of glucose and ketone bodies, while adipose tissue will provide fatty acids to the bloodstream for other peripheral tissues to use during fasting.

This podcast summarizes the key biochemical components of metabolism, including: 1. definition; 2. cellular location; 3. the major catabolic pathways; 4. the 3 stages of catabolism; 5. the 12 major metabolic uses of glucose, fatty acids and amino acids; 6. the energy output of catabolism of glucose, fatty acids, and ketone bodies.

This podcast covers 5 distinct enzyme regulatory mechanisms and their effects on enzyme structure and activity.

This podcast covers the function and the location of the urea cycle, including some key features and the sequence of the enzymes as well as their location.

This podcast covers the role of transaminases the initial step in the degradation of amino acids. This includes the role of glutamate dehydrogenase in producing ammonia. The ammonia and aspartate produced are then able to enter the urea cycle in the liver.

This podcast covers the role of adipocytes in energy storage and their role in initiating lypolysis of stored triacylglycerols to provide various tissues with fatty acids as a energy source. The role of fatty acid Beta-oxidation in providing energy from both dietary or stored triacylglycerols is also covered.

This podcast covers the details of the conversion of lactate produced during exercise to glucose in the liver and ultimately releasing it to the bloodstream.

This pocast covers the regulation of the Rate-limiting enzyme in fatty acid synthesis, Acetyl CoA Carboxylase allosterically, and by covalent modification.

This podcast covers the regulation of HMG CoA Reductase by hormones, covalent modification, cytoplasmic cholesterol, and statins.

This podcast defines metabolism and its two distinct components: anabolism and catabolism. The major compartments involved in both are also covered. If you like this podcast, feel free to donate to the podcast.

This podcast covers the distinct uses of glucose, fatty acids, and amino acids and their unique roles in metabolism.

This podcast covers the key role of the liver and adipose tissue in providing energy sources to the plasma during fasting. The liver is the provider of glucose and fatty acids, while adipose tissue provides fatty acids to the bloodstream.

While following a ketogenic diet, maintenance of plasma glucose is essential for several tissues. The amino acids derived from dietary proteins will provide the carbon skeletons for glucose synthesis by the liver, while the triacylglycerols from dietary fat will provide the energy for various tissues through Beta-oxidation of fatty acids.

This podcast covers the production of cAMP by activation of either the beta-adrenergic receptor or the glucagon receptor as well as the activation of the alpha1-adrenergic by epinephrine to produce IP3, DG and calcium.

This podcast covers the major pathways for catabolism of glucose and fatty acids, including the ATP output from their complete degradation to CO2. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the target enzymes of NSAIDS and cortisol and their respective effects on inflammation. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the effect of phophorylstion/dephosphorylation by protein kinases and phosphatases on enzyme activity. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the activation of the Insulin receptor resulting in activation of an intracellular protein phosphatase. The deposphorylation of eight enzymes is also covered. This dephosphorylation results in profound effects on carbohydrate, lipid and protein metabolism. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the key tissue effects of insulin in the well-fed state including its effects on liver, muscle and adipose tissue. Also covered are the effects of insulin on regulating key enzymes involved in carbohydrate and lipid metabolism.

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This podcast describes the digestion, reassembly, absorption and storage of dietary Triacylglycerol including the role of pancreatic lipase and lipoprotein lipase. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the liver output of glucose during fasting and its regulation by glucagon. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the phosphorylation of enzymes by protein kinases that modify specific hydroxyl residues in enzymes. This content may be useful to premedical and medical students. Similar biochemistry content is available at: MEDBIOCHEM.ORG

This podcast describes the specific mechanism by which statins reduce plasma cholesterol. The reduction of cholesterol synthesis by statins in effect, will result in the upregulation of the LDL receptor and increased uptake of LDL from plasma. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the specific metabolic effects of insulin on liver, muscle and adipose tissue. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the key components of the adenylate cyclase system including receptor activation, G-protein involved, activation of adenylate cyclase , production of cAMP, activation of PKA and termination of the actions of cAMP . Also included is a historical perspective of the discovery of G-proteins the adeylate cyclase system.

This podcast describes the effect of cortisol on eicosanoid biosynthesis and its resulting anti-inflammatory effects. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the only 2 enzymes that require Vitamin B12 . This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the 4 enzymes requiring thiamine as a coenzyme. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the carbon skeletons derived from amino acids and their classification as glucogenic or ketogenic. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the major sources of NADPH and its primary uses in 5 biological reactions. This content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the regulation of acetyl CoA Carboxylase allosterically and by covalent modification. The effect of malonyl CoA on beta oxidation of fatty acids is also described. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the molecules that can produce acetyl CoA as well as the possible metabolic fates of acetyl CoA. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast is an overview of the components of metabolism, namely, catabolism and anabolism and their respective cellular functions. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the purine salvage pathway and the inherited deficiency in the salvage of hypoxanthine and guanine (HGPRT) and its outcome in infants. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG.

This podcast covers the mutual regulation of glycolysis and gluconeogenesis by allosteric regulators, thus preventing the likelihood of a futile cycle from occurring. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the underlying changes associated with insulin resistance and resulting in dyslipidemia. These changes include effects on two key lipases namely, Lipoprotein Lipase and Hormone-Sensitive Lipase. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes one of the key outcomes of insulin resistance, hyperglycemia, including the specific tissue contributions to the rise in plasma glucose. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the underlying changes associated with insulin resistance and its consequences in both plasma and target tissues. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast is a summary of the biosynthesis of non-essential amino acids from their respective carbon skeletons. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the signals for insulin secretion by the pancreas and the molecular mechanism behind its secretion by the islets of Langerhans beta cells. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the role of cytosolic citrate in regulating glycolysis, fatty acid synthesis and providing thd vehicle to transport Acetyl CoA to the cytoplasm where it is needed for lipid synthesis. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast covers the fifth unique liver function in its ability to detoxify organic molecules by making them more water soluble. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG

This podcast describes the role of the Urea cycle in detoxifying ammonia as the fifth unique function of the liver. This biochemistry content may be useful to premedical and medical students.Similar content is available at:MEDBIOCHEM.ORG

This podcast describes the second unique role of the liver in cholesterol biosynthesis, storage and uptake of LDL from plasma. This biochemistry content may be useful to premedical and medical students. Similar content is available at: MEDBIOCHEM.ORG Check out my YouTube playlist:https://youtube.com/playlist?list=PLXy2KYiCd9rlg0JmfA392WrEiOYNu39xn