にゃんごう＆いがさんのEBMerな夜

にゃんごう＆いがさんのEBMerな夜 第74回放送　2023/1/30 【にゃんごう：不定愁訴をきたす患者の癌リスク】 White B, Renzi C, Barclay M, Lyratzopoulos G. Underlying cancer risk among patients with fatigue and other vague symptoms: a population-based cohort study in primary care. Br J Gen Pract. 2023 Jan 26;73(727):e75-e87. doi: 10.3399/BJGP.2022.0371. PMID: 36702593. https://bjgp.org/content/73/727/e75.full 【いがさん：コロナワクチン接種者におけるCOVID-19に対するモヌルピラビルの効果】 Butler CC, Hobbs FDR, Gbinigie OA, Rahman NM, Hayward G, Richards DB, Dorward J, Lowe DM, Standing JF, Breuer J, Khoo S, Petrou S, Hood K, Nguyen-Van-Tam JS, Patel MG, Saville BR, Marion J, Ogburn E, Allen J, Rutter H, Francis N, Thomas NPB, Evans P, Dobson M, Madden TA, Holmes J, Harris V, Png ME, Lown M, van Hecke O, Detry MA, Saunders CT, Fitzgerald M, Berry NS, Mwandigha L, Galal U, Mort S, Jani BD, Hart ND, Ahmed H, Butler D, McKenna M, Chalk J, Lavallee L, Hadley E, Cureton L, Benysek M, Andersson M, Coates M, Barrett S, Bateman C, Davies JC, Raymundo-Wood I, Ustianowski A, Carson-Stevens A, Yu LM, Little P; PANORAMIC Trial Collaborative Group. Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial. Lancet. 2023 Jan 28;401(10373):281-293. doi: 10.1016/S0140-6736(22)02597-1. Epub 2022 Dec 22. PMID: 36566761; PMCID: PMC9779781. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)02597-1/fulltext リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2

にゃんごう＆いがさんのEBMerな夜 第73回放送　2022/12/30 BMJクリスマス号2022 https://www.bmj.com/specialties/christmas 【にゃんごう1】 Evaluation of editors’ abilities to predict the citation potential of research manuscripts submitted to The BMJ: a cohort study BMJに投稿された研究原稿の引用可能性を予測する編集者の能力の評価：コホート研究 Published 14 December 2022 BMJ 2022;379:e073880 https://www.bmj.com/content/379/bmj-2022-073880 【いがさん1】 A Christmas themed physical activity intervention to increase participation in physical activity during Advent: pilot randomised controlled trial アドベント期間中の身体活動への参加を増やすためのクリスマスをテーマとした身体活動介入：パイロット無作為化対照試験 Published 19 December 2022 BMJ 2022;379:e072807 https://www.bmj.com/content/379/bmj-2022-072807 【にゃんごう2】 Direct Uptake of Nutrition and Caffeine Study (DUNCS): biscuit based comparative study Direct Uptake of Nutrition and Caffeine Study (DUNCS)：ビスケットを用いた比較試験 Published 19 December 2022 BMJ 2022;379:e072839 https://www.bmj.com/content/379/bmj-2022-072839 【いがさん2】 Quantifying the benefits of inefficient walking: Monty Python inspired laboratory based experimental study 非効率的なウォーキングの利点の定量化。モンティ・パイソンにインスパイアされた実験室ベースの実験的研究 Published 21 December 2022 BMJ 2022;379:e072833 https://www.bmj.com/content/379/bmj-2022-072833 【にゃんごう3】 Digital disparities among healthcare workers in typing speed between generations, genders, and medical specialties: cross sectional study 医療従事者のタイピング速度における世代間、性別、診療科間のデジタル格差：横断的研究 Published 19 December 2022 BMJ 2022;379:e072784 https://www.bmj.com/content/379/bmj-2022-072784 【いがさん3】 Can artificial intelligence pass the Fellowship of the Royal College of Radiologists examination? Multi-reader diagnostic accuracy study 人工知能は英国王立放射線科学会（Fellowship of the Royal College of Radiologists）の試験に合格できるのか？マルチリーダーによる診断精度の検討 Published 21 December 2022 BMJ 2022;379:e072826 https://www.bmj.com/content/379/bmj-2022-072826 【いがさん3－関連論文】 Measuring human energy expenditure: public health application to counter inactivity ヒトのエネルギー消費量の測定：運動不足対策としての公衆衛生への応用 Published 21 December 2022 BMJ 2022;379:o2937 https://www.bmj.com/content/379/bmj.o2937 【にゃんごう4】 Alcohol related disorders among elite male football players in Sweden: nationwide cohort study スウェーデンのエリート男子サッカー選手におけるアルコール関連障害：全国規模のコホート研究 Published 21 December 2022 BMJ 2022;379:e074093 https://www.bmj.com/content/379/bmj-2022-074093 【いがさん4】 Everything causes cancer? Beliefs and attitudes towards cancer prevention among anti-vaxxers, flat earthers, and reptilian conspiracists: online cross sectional survey すべてが癌の原因？アンチワクシング派、フラットアース派、レプティリアン陰謀論者のがん予防に対する信念と態度：オンライン断面調査 Published 21 December 2022 BMJ 2022;379:e072561 https://www.bmj.com/content/379/bmj-2022-072561 リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2

にゃんごう＆いがさんのEBMerな夜 第72回放送　2022/11/29 【にゃんごう：フィブラート】 Das Pradhan A, Glynn RJ, Fruchart JC, MacFadyen JG, Zaharris ES, Everett BM, Campbell SE, Oshima R, Amarenco P, Blom DJ, Brinton EA, Eckel RH, Elam MB, Felicio JS, Ginsberg HN, Goudev A, Ishibashi S, Joseph J, Kodama T, Koenig W, Leiter LA, Lorenzatti AJ, Mankovsky B, Marx N, Nordestgaard BG, Páll D, Ray KK, Santos RD, Soran H, Susekov A, Tendera M, Yokote K, Paynter NP, Buring JE, Libby P, Ridker PM; PROMINENT Investigators. Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk. N Engl J Med. 2022 Nov 24;387(21):1923-1934. doi: 10.1056/NEJMoa2210645. Epub 2022 Nov 5.  PMID: 36342113. https://www.nejm.org/doi/10.1056/NEJMoa2210645 【いがさん：COVID-19学校マスク】 Cowger TL, Murray EJ, Clarke J, Bassett MT, Ojikutu BO, Sanchez SM, Linos N, Hall KT. Lifting Universal Masking in Schools - Covid-19 Incidence among Students and Staff. N Engl J Med. 2022 Nov 24;387(21):1935-1946. doi: 10.1056/NEJMoa2211029. Epub 2022 Nov 9. PMID: 36351262. https://www.nejm.org/doi/10.1056/NEJMoa2211029 pES club 第22回EBM Seminar 2022年12月4日（日）　14：00～18：00（終了後，オンライン懇親会あり） 学生を対象としたEBM初学者セミナーです．EBMの流れが一通り体験できる半日コースです． http://spell.umin.jp/pES_club_Seminar_Subscription.html リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2

にゃんごう＆いがさんのEBMerな夜 第71回放送　2022/10/30 【にゃんごう：降圧薬服用タイミング】 Mackenzie IS, Rogers A, Poulter NR, Williams B, Brown MJ, Webb DJ, Ford I, Rorie DA, Guthrie G, Grieve JWK, Pigazzani F, Rothwell PM, Young R, McConnachie A, Struthers AD, Lang CC, MacDonald TM; TIME Study Group. Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial. Lancet. 2022 Oct 22;400(10361):1417-1425. doi: 10.1016/S0140-6736(22)01786-X. Epub 2022 Oct 11. PMID: 36240838. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01786-X/fulltext 【いがさん：リアルワールドにおける臨床試験で除外された患者】 Tan YY, Papez V, Chang WH, Mueller SH, Denaxas S, Lai AG. Comparing clinical trial population representativeness to real-world populations: an external validity analysis encompassing 43 895 trials and 5 685 738 individuals across 989 unique drugs and 286 conditions in England. Lancet Healthy Longev. 2022 Oct;3(10):e674-e689. doi: 10.1016/S2666-7568(22)00186-6. Epub 2022 Sep 20. PMID: 36150402. https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(22)00186-6/fulltext リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2

にゃんごう＆いがさんのEBMerな夜 第70回放送　2022/9/27 【にゃんごう：メトホルミンを使用している2型糖尿病へ追加する次の抗糖尿病薬】 GRADE Study Research Group, Nathan DM, Lachin JM, Bebu I, Burch HB, Buse JB, Cherrington AL, Fortmann SP, Green JB, Kahn SE, Kirkman MS, Krause-Steinrauf H, Larkin ME, Phillips LS, Pop-Busui R, Steffes M, Tiktin M, Tripputi M, Wexler DJ, Younes N; The GRADE Study Research Group.  Glycemia Reduction in Type 2 Diabetes - Microvascular and Cardiovascular Outcomes. N Engl J Med. 2022 Sep 22;387(12):1075-1088. doi: 10.1056/NEJMoa2200436. PMID: 36129997. https://www.nejm.org/doi/full/10.1056/NEJMoa2200436 MNSI http://spell.umin.jp/nangoroku/nangoroku_diabeticmicroangiopathy.html#DMneuropathyMNSI 【いがさん：インフルエンザワクチン反復接種の効果減弱】 Jones-Gray E, Robinson EJ, Kucharski AJ, Fox A, Sullivan SG. Does repeated influenza vaccination attenuate effectiveness? A systematic review and meta-analysis Lancet Respir Med. 2022 Sep 21. doi: 10.1016/S2213-2600(22)00266-1 https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(22)00266-1/fulltext 日本プライマリ・ケア連合学会　第19回秋季生涯教育セミナー オンデマンド配信期間：10月3日（月）※予定～11月30日（水） https://www.primary-care.or.jp/seminar_c/20220924/index.html リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2

にゃんごう＆いがさんのEBMerな夜 第69回放送　2022/8/31 【にゃんごう：HFpEFに対するSGLT2阻害薬】 Solomon SD, McMurray JJV, Claggett B, de Boer RA, DeMets D, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F, Shah SJ, Desai AS, Jhund PS, Belohlavek J, Chiang CE, Borleffs CJW, Comin-Colet J, Dobreanu D, Drozdz J, Fang JC, Alcocer-Gamba MA, Al Habeeb W, Han Y, Cabrera Honorio JW, Janssens SP, Katova T, Kitakaze M, Merkely B, O'Meara E, Saraiva JFK, Tereshchenko SN, Thierer J, Vaduganathan M, Vardeny O, Verma S, Pham VN, Wilderang U, Zaozerska N, Bachus E, Lindholm D, Petersson M, Langkilde AM; DELIVER Trial Committees and Investigators. Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction. N Engl J Med. 2022 Aug 27. doi: 10.1056/NEJMoa2206286. Epub ahead of print. PMID: 36027570. https://www.nejm.org/doi/10.1056/NEJMoa2206286 【いがさん：発熱患者の解熱治療】 Holgersson J, Ceric A, Sethi N, Nielsen N, Jakobsen JC. Fever therapy in febrile adults: systematic review with meta-analyses and trial sequential analyses. BMJ. 2022 Jul 12;378:e069620. doi: 10.1136/bmj-2021-069620. PMID: 35820685; PMCID: PMC9274300. https://www.bmj.com/content/378/bmj-2021-069620.long リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2 にゃんごうの解説で紹介したメタアナリシスの論文． Vaduganathan M, Docherty KF, Claggett BL, Jhund PS, de Boer RA, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F, Shah SJ, Desai AS, McMurray JJV, Solomon SD. SGLT-2 inhibitors in patients with heart failure: a comprehensive meta-analysis of five randomised controlled trials. Lancet. 2022 Aug 26:S0140-6736(22)01429-5. doi: 10.1016/S0140-6736(22)01429-5. Epub ahead of print. PMID: 36041474. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)01429-5/fulltext

にゃんごう＆いがさんのEBMerな夜 第68回放送　2022/7/31 【にゃんごう：PPI不適切処方】 Koggel L, Lantinga M, Buchner F, Drenth J, Frankema J, Heeregrave E, Heringa M, Numan, M, Siersema P. Predictors for inappropriate proton pump inhibitor use: observational study in primary care. Br J Gen Pract. 2022 June 20. doi: 10.3399/BJGP.2022.0178 https://bjgp.org/content/early/2022/06/24/BJGP.2022.0178 【いがさん：コロナワクチン不接種理由】 Nomura S, Eguchi A, Yoneoka D, Murakami M, Ghaznavi C, Gilmour S, Kaneko S, Kawashima T, Kunishima H, Naito W, Sakamoto H, Maruyama-Sakurai K, Takahashi A, Takayama Y, Tanoue Y, Yamamoto Y, Yasutaka T, Miyata H. Characterising reasons for reversals of COVID-19 vaccination hesitancy among Japanese people: One-year follow-up survey. Lancet Reg Health West Pac. 2022 Jul 21:100541. doi: 10.1016/j.lanwpc.2022.100541. Epub ahead of print. PMID: 35892010; PMCID: PMC9302916. https://www.thelancet.com/journals/lanwpc/article/PIIS2666-6065(22)00156-0/fulltext リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2

にゃんごう＆いがさんのEBMerな夜 第67回放送　2022/6/29 【いがさん：帝王切開で生まれた子どもに対する切開前と臍帯締付後の予防的抗菌薬使用の長期的影響】 ?umilo D, Nirantharakumar K, Willis BH, Rudge G, Martin J, Gokhale K, Thayakaran R, Adderley NJ, Chandan JS, Okoth K, Hewston R, Skrybant M, Deeks JJ, Brocklehurst P. Long-term impact of giving antibiotics before skin incision versus after cord clamping on children born by caesarean section: protocol for a longitudinal study based on UK electronic health records. BMJ Open. 2019 Sep 26;9(9):e033013. doi: 10.1136/bmjopen-2019-033013. PMID: 31558464; PMCID: PMC6773283. https://www.bmj.com/content/377/bmj-2021-069704 【にゃんごう：費用対効果分析におけるスポンサーシップバイアス】 Xie F, Zhou T. Industry sponsorship bias in cost effectiveness analysis: registry based analysis. BMJ. 2022 Jun 22;377:e069573. doi: 10.1136/bmj-2021-069573. PMID: 35732297. https://www.bmj.com/content/377/bmj-2021-069573 リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2

にゃんごう＆いがさんのEBMerな夜 第66回放送　2022/5/31 第13回日本プライマリ・ケア連合学会学術大会 2022年6月11日（土）～12日（日） パシフィコ横浜 https://jpca2022.org/ リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2

にゃんごう＆いがさんのEBMerな夜 第65回放送　2022/4/24 【にゃんごう：アルツハイマー型認知症予防のためのライフスタイル】 Dhana K, Franco OH, Ritz EM, Ford CN, Desai P, Krueger KR, Holland TM, Dhana A, Liu X, Aggarwal NT, Evans DA, Rajan KB. Healthy lifestyle and life expectancy with and without Alzheimer's dementia: population based cohort study. BMJ. 2022 Apr 13;377:e068390. doi: 10.1136/bmj-2021-068390. PMID: 35418416. https://www.bmj.com/content/377/bmj-2021-068390 【いがさん：尿路感染症に対するテビペネム・ピボキシル臭化水素酸塩】 Eckburg PB, Muir L, Critchley IA, Walpole S, Kwak H, Phelan AM, Moore G, Jain A, Keutzer T, Dane A, Melnick D, Talley AK. Oral Tebipenem Pivoxil Hydrobromide in Complicated Urinary Tract Infection. N Engl J Med. 2022 Apr 7;386(14):1327-1338. doi: 10.1056/NEJMoa2105462. PMID: 35388666. https://www.nejm.org/doi/full/10.1056/NEJMoa2105462 リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2

にゃんごう＆いがさんのEBMerな夜 第64回放送　2022/4/3 【にゃんごう：ACE阻害薬による肺炎予防】 Tsunoda, H, Okami, Y, Honda, Y, Shiroshita, A, Kataoka, Y, Tsujimoto, Y, et al. Effectiveness of angiotensin converting enzyme inhibitors in preventing pneumonia: A systematic review and meta-analysis. J Gen Fam Med. 2022; 00: 1-11. https://onlinelibrary.wiley.com/doi/10.1002/jgf2.532 【いがさん：尿路感染予防のための馬尿酸メテナミン】 Harding C, Mossop H, Homer T, Chadwick T, King W, Carnell S, Lecouturier J, Abouhajar A, Vale L, Watson G, Forbes R, Currer S, Pickard R, Eardley I, Pearce I, Thiruchelvam N, Guerrero K, Walton K, Hussain Z, Lazarowicz H, Ali A. Alternative to prophylactic antibiotics for the treatment of recurrent urinary tract infections in women: multicentre, open label, randomised, non-inferiority trial. BMJ. 2022 Mar 9;376:e068229. doi: 10.1136/bmj-2021-0068229. PMID: 35264408; PMCID: PMC8905684. https://www.bmj.com/content/376/bmj-2021-0068229 リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2

にゃんごう＆いがさんのEBMerな夜 第63回放送　2022/2/20 【にゃんごう：在宅患者の敗血症予測の単純化予測モデル】 Feike J Loots, Marleen Smits, Rogier Hopstaken, Kevin Jenniskens, Fleur H Schroeten, Ann Van den Bruel, Alma C van de Pol, Jan-Jelrik Oosterheert, Hjalmar Bouma, Paul Little, Michael Moore, Sanne van Delft, Douwe Rijpsma, Joris Holkenborg, Bas CT van Bussel, Ralph Laven, Dennis CJJ Bergmans, Jacobien J Hoogerwerf, Gideon Latten, Eefje de Bont, Paul Giesen, Annemarie den Harder, Ron Kusters, Arthur van Zanten and Theo JM Verheij Development and external validation of a new clinical prediction model for early recognition of sepsis in adult patients in primary care: a diagnostic study British Journal of General Practice 16 February 2022; BJGP.2021.0520. https://bjgp.org/content/early/2022/02/14/BJGP.2021.0520.abstract 【いがさん：ハイリスク非入院COVID-19に対する経口Nirmatrelvir】 Hammond J, Leister-Tebbe H, Gardner A, Abreu P, Bao W, Wisemandle W, Baniecki M, Hendrick VM, Damle B, Simon-Campos A, Pypstra R, Rusnak JM; EPIC-HR Investigators. Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19. N Engl J Med. 2022 Feb 16. doi: 10.1056/NEJMoa2118542. Epub ahead of print. PMID: 35172054. https://www.nejm.org/doi/full/10.1056/NEJMoa2118542 リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2

にゃんごう＆いがさんのEBMerな夜 第62回放送　2022/2/6 【にゃんごう：2型糖尿病患者における葉酸とビタミンB12】 Liu Y, Geng T, Wan Z, Lu Q, Zhang X, Qiu Z, Li L, Zhu K, Liu L, Pan A, Liu G. Associations of Serum Folate and Vitamin B12 Levels With Cardiovascular Disease Mortality Among Patients With Type 2 Diabetes. JAMA Netw Open. 2022 Jan 4;5(1):e2146124. doi: 10.1001/jamanetworkopen.2021.46124. PMID: 35099545. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2788494 【いがさん：重度の自殺企図に対するケタミン】 Abbar M, Demattei C, El-Hage W, Llorca PM, Samalin L, Demaricourt P, Gaillard R, Courtet P, Vaiva G, Gorwood P, Fabbro P, Jollant F. Ketamine for the acute treatment of severe suicidal ideation: double blind, randomised placebo controlled trial. BMJ. 2022 Feb 2;376:e067194. doi: 10.1136/bmj-2021-067194. PMID: 35110300. https://www.bmj.com/content/376/bmj-2021-067194 リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2

にゃんごう＆いがさんのEBMerな夜 第61回放送　2021/12/24 BMJクリスマス号2021 https://www.bmj.com/specialties/christmas 【にゃんごう】 Ghost in the machine or monkey with a typewriter?generating titles for Christmas research articles in The BMJ using artificial intelligence: observational study タイプライターを持った機械または猿の幽霊?人工知能を使用してBMJのクリスマス研究記事のタイトルを生成する：観察研究 https://www.bmj.com/content/375/bmj-2021-067732 “It’s not rocket science” and “It’s not brain surgery”?“It’s a walk in the park”: prospective comparative study 「ロケット科学ではない」と「脳外科手術ではない」?「公園を散歩している」：前向き比較研究 https://www.bmj.com/content/375/bmj-2021-067883 Bah humbug! Association between sending Christmas cards to trial participants and trial retention: randomised study within a trial conducted simultaneously across eight host trials ばかばかしい！試験参加者へのクリスマスカード送付と試験継続の関連性：8つのホスト試験で同時に実施された試験内の無作為化試験 https://www.bmj.com/content/375/bmj-2021-067742 The holly and the ivy: a festive platter of plant hazards ヒイラギとツタ：植物の危険のお祝いの盛り合わせ https://www.bmj.com/content/375/bmj-2021-066995 Biased Outcome reporting Guidelines for Underwhelming Studies (BOGUS) statement and checklist 圧倒的研究のための偏った結果報告ガイドライン（BOGUS）声明とチェックリスト https://www.bmj.com/content/375/bmj-2021-067350 【いがさん】 Giving science the finger?is the second-to-fourth digit ratio (2D:4D) a biomarker of good luck? A cross sectional study 科学に指を与える-2桁目と4桁目の比率（2D:4D）は幸運のバイオマーカーなのか？横断的研究 https://www.bmj.com/content/375/bmj-2021-067849 Heavy metal toxicity and mortality?association between density of heavy metal bands and cause specific hospital admissions and mortality: population based cohort study ヘヴィメタル中毒と死亡率-ヘヴィメタルバンドの密度と原因別の入院および死亡との関連性：人口ベースのコホート研究 https://www.bmj.com/content/375/bmj-2021-067633 Association of Logic’s hip hop song “1-800-273-8255” with Lifeline calls and suicides in the United States: interrupted time series analysis Logicのヒップホップソング「1-800-273-8255」と米国のライフラインコールおよび自殺との関連：時系列分析の中断 https://www.bmj.com/content/375/bmj-2021-067726 Anticipating the ageing trajectories of superheroes in the Marvel cinematic universe マーベルシネマティックユニバースのスーパーヒーローの老化の軌跡を予測する https://www.bmj.com/content/375/bmj-2021-068001 We all fall down: head injuries in nursery rhyme characters 私たちは皆倒れます：童謡のキャラクターの頭部外傷 https://www.bmj.com/content/375/bmj-2021-068256 リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2

にゃんごう＆いがさんのEBMerな夜 第60回放送　2021/11/24 【にゃんごう：ビスフォスフォネート効果発現までの期間】 Deardorff WJ, Cenzer I, Nguyen B, Lee SJ. Time to Benefit of Bisphosphonate Therapy for the Prevention of Fractures Among Postmenopausal Women With Osteoporosis: A Meta-analysis of Randomized Clinical Trials. JAMA Intern Med. 2021 Nov 22. doi: 10.1001/jamainternmed.2021.6745. Epub ahead of print. PMID: 34807231. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2786013 【いがさん：禁煙に対するバレニクリンとニコチンパッチの併用】 Baker TB, Piper ME, Smith SS, Bolt DM, Stein JH, Fiore MC. Effects of Combined Varenicline With Nicotine Patch and of Extended Treatment Duration on Smoking Cessation: A Randomized Clinical Trial. JAMA. 2021 Oct 19;326(15):1485-1493. doi: 10.1001/jama.2021.15333. PMID: 34665204; PMCID: PMC8527361. https://jamanetwork.com/journals/jama/article-abstract/2785264 リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2

にゃんごう＆いがさんのEBMerな夜 第59回放送　2021/10/31 【にゃんごう：尿閉とがんのリスク】 Bengtsen MB, Farkas DK, Borre M, Sørensen HT, Nørgaard M. Acute urinary retention and risk of cancer: population based Danish cohort study. BMJ. 2021 Oct 19;375:n2305. doi: 10.1136/bmj.n2305. PMID: 34666981. https://www.bmj.com/content/375/bmj.n2305 【いがさん：迅速承認された抗がん剤の否定的な試験の扱い】 Gyawali B, Rome BN, Kesselheim AS. Regulatory and clinical consequences of negative confirmatory trials of accelerated approval cancer drugs: retrospective observational study. BMJ. 2021 Sep 8;374:n1959. doi: 10.1136/bmj.n1959. PMID: 34497044; PMCID: PMC8424519. https://www.bmj.com/content/374/bmj.n1959 リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2

にゃんごう＆いがさんのEBMerな夜 第58回特別編～ゲリラライヴジャーナルクラブ～放送　2021/9/23 【にゃんごう：診療日数が患者アウトカムに与える影響】 O'Brien MP, Forleo-Neto E, Musser BJ, Isa F, Chan KC, Sarkar N, Bar KJ, Barnabas RV, Barouch DH, Cohen MS, Hurt CB, Burwen DR, Marovich MA, Hou P, Heirman I, Davis JD, Turner KC, Ramesh D, Mahmood A, Hooper AT, Hamilton JD, Kim Y, Purcell LA, Baum A, Kyratsous CA, Krainson J, Perez-Perez R, Mohseni R, Kowal B, DiCioccio AT, Stahl N, Lipsich L, Braunstein N, Herman G, Yancopoulos GD, Weinreich DM; Covid-19 Phase 3 Prevention Trial Team. Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19. N Engl J Med. 2021 Sep 23;385(13):1184-1195. doi: 10.1056/NEJMoa2109682. Epub 2021 Aug 4. PMID: 34347950; PMCID: PMC8362593. https://www.nejm.org/doi/full/10.1056/NEJMoa2109682 リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2

にゃんごう＆いがさんのEBMerな夜 第57回放送　2021/9/23 【にゃんごう：診療日数が患者アウトカムに与える影響】 Kato H, Jena AB, Figueroa JF, Tsugawa Y. Association Between Physician Part-time Clinical Work and Patient Outcomes. JAMA Intern Med. 2021 Sep 13. doi: 10.1001/jamainternmed.2021.5247. Epub ahead of print. PMID: 34515730. https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2784166 【いがさん：代用塩の心血管イベント抑制効果】 Neal B, Wu Y, Feng X, Zhang R, Zhang Y, Shi J, Zhang J, Tian M, Huang L, Li Z, Yu Y, Zhao Y, Zhou B, Sun J, Liu Y, Yin X, Hao Z, Yu J, Li KC, Zhang X, Duan P, Wang F, Ma B, Shi W, Di Tanna GL, Stepien S, Shan S, Pearson SA, Li N, Yan LL, Labarthe D, Elliott P. Effect of Salt Substitution on Cardiovascular Events and Death. N Engl J Med. 2021 Sep 16;385(12):1067-1077. doi: 10.1056/NEJMoa2105675. Epub 2021 Aug 29. PMID: 34459569. https://www.nejm.org/doi/full/10.1056/NEJMoa2105675 リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2

にゃんごう＆いがさんのEBMerな夜 第56回放送　2021/8/21 【いがさん：デング熱の制御のためのボルバキアに感染した蚊の展開の有効性】 Utarini A, Indriani C, Ahmad RA, Tantowijoyo W, Arguni E, Ansari MR, Supriyati E, Wardana DS, Meitika Y, Ernesia I, Nurhayati I, Prabowo E, Andari B, Green BR, Hodgson L, Cutcher Z, Rances E, Ryan PA, O'Neill SL, Dufault SM, Tanamas SK, Jewell NP, Anders KL, Simmons CP; AWED Study Group. Efficacy of Wolbachia-Infected Mosquito Deployments for the Control of Dengue. N Engl J Med. 2021 Jun 10;384(23):2177-2186. doi: 10.1056/NEJMoa2030243. PMID: 34107180; PMCID: PMC8103655. https://www.nejm.org/doi/full/10.1056/NEJMoa2030243 【にゃんごう：合併症のリスクが高い人々におけるCOVID-19の吸入ブデソニド】 Yu LM, Bafadhel M, Dorward J, Hayward G, Saville BR, Gbinigie O, Van Hecke O, Ogburn E, Evans PH, Thomas NPB, Patel MG, Richards D, Berry N, Detry MA, Saunders C, Fitzgerald M, Harris V, Shanyinde M, de Lusignan S, Andersson MI, Barnes PJ, Russell REK, Nicolau DV Jr, Ramakrishnan S, Hobbs FDR, Butler CC; PRINCIPLE Trial Collaborative Group. Inhaled budesonide for COVID-19 in people at high risk of complications in the community in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial. Lancet. 2021 Aug 10:S0140-6736(21)01744-X. doi: 10.1016/S0140-6736(21)01744-X. Epub ahead of print. PMID: 34388395; PMCID: PMC8354567. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01744-X/fulltext リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2

にゃんごう＆いがさんのEBMerな夜 第55回放送　2021/8/1 【いがさん：乳癌アジュバント化学療法期間】 Gnant M, Fitzal F, Rinnerthaler G, Steger GG, Greil-Ressler S, Balic M, Heck D, Jakesz R, Thaler J, Egle D, Manfreda D, Bjelic-Radisic V, Wieder U, Singer CF, Melbinger-Zeinitzer E, Haslbauer F, Sevelda P, Trapl H, Wette V, Wimmer K, Gampenrieder SP, Bartsch R, Kacerovsky-Strobl S, Suppan C, Brunner C, Deutschmann C, Soelkner L, Fesl C, Greil R; Austrian Breast and Colorectal Cancer Study Group. Duration of Adjuvant Aromatase-Inhibitor Therapy in Postmenopausal Breast Cancer. N Engl J Med. 2021 Jul 29;385(5):395-405. doi: 10.1056/NEJMoa2104162. PMID: 34320285. https://www.nejm.org/doi/full/10.1056/NEJMoa2104162 【にゃんごう：男性無熱性UTIに対する抗菌薬治療期間】 Drekonja DM, Trautner B, Amundson C, Kuskowski M, Johnson JR. Effect of 7 vs 14 Days of Antibiotic Therapy on Resolution of Symptoms Among Afebrile Men With Urinary Tract Infection: A Randomized Clinical Trial. JAMA. 2021 Jul 27;326(4):324-331. doi: 10.1001/jama.2021.9899. PMID: 34313686. https://jamanetwork.com/journals/jama/article-abstract/2782300 リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2

にゃんごう＆いがさんのEBMerな夜 第54回放送　2021/6/26 【いがさん：健康アプリ】 Tangari G, Ikram M, Ijaz K, Kaafar MA, Berkovsky S. Mobile health and privacy: cross sectional study. BMJ. 2021 Jun 16;373:n1248. doi: 10.1136/bmj.n1248. PMID: 34135009. https://www.bmj.com/content/373/bmj.n1248 【にゃんごう：KDIGO CKD血圧管理診療ガイドライン2021】 Tomson CRV, Cheung AK, Mann JFE, Chang TI, Cushman WC, Furth SL, Hou FF, Knoll GA, Muntner P, Pecoits-Filho R, Tobe SW, Lytvyn L, Craig JC, Tunnicliffe DJ, Howell M, Tonelli M, Cheung M, Earley A, Ix JH, Sarnak MJ. Management of Blood Pressure in Patients With Chronic Kidney Disease Not Receiving Dialysis: Synopsis of the 2021 KDIGO Clinical Practice Guideline. Ann Intern Med. 2021 Jun 22. doi: 10.7326/M21-0834. Epub ahead of print. PMID: 34152826. https://www.acpjournals.org/doi/10.7326/M21-0834 リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2

にゃんごう＆いがさんのEBMerな夜 第53回放送　2021/5/27 【いがさん：低出生体重児に対する即時カンガルーケア 】 WHO Immediate KMC Study Group, Arya S, Naburi H, Kawaza K, Newton S, Anyabolu CH, Bergman N, Rao SPN, Mittal P, Assenga E, Gadama L, Larsen-Reindorf R, Kuti O, Linner A, Yoshida S, Chopra N, Ngarina M, Msusa AT, Boakye-Yiadom A, Kuti BP, Morgan B, Minckas N, Suri J, Moshiro R, Samuel V, Wireko-Brobby N, Rettedal S, Jaiswal HV, Sankar MJ, Nyanor I, Tiwary H, Anand P, Manu AA, Nagpal K, Ansong D, Saini I, Aggarwal KC, Wadhwa N, Bahl R, Westrup B, Adejuyigbe EA, Plange-Rhule G, Dube Q, Chellani H, Massawe A. Immediate "Kangaroo Mother Care" and Survival of Infants with Low Birth Weight. N Engl J Med. 2021 May 27;384(21):2028-2038. doi: 10.1056/NEJMoa2026486. PMID: 34038632. https://www.nejm.org/doi/full/10.1056/NEJMoa2026486 【にゃんごう：Long COVID】 Nasserie T, Hittle M, Goodman SN. Assessment of the Frequency and Variety of Persistent Symptoms Among Patients With COVID-19: A Systematic Review. JAMA Netw Open. 2021 May 3;4(5):e2111417. doi: 10.1001/jamanetworkopen.2021.11417. PMID: 34037731. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2780376 リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2

にゃんごう＆いがさんのEBMerな夜 第52回放送　2021/4/30 【にゃんごう：禁煙後の体重増加】 Sahle BW, Chen W, Rawal LB, Renzaho AMN. Weight Gain After Smoking Cessation and Risk of Major Chronic Diseases and Mortality. JAMA Netw Open. 2021 Apr 1;4(4):e217044. doi: 10.1001/jamanetworkopen.2021.7044. PMID: 33904915. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2779121 【いがさん：大腸癌術後標準的化学療法へのセレコキシブの追加】 Meyerhardt JA, Shi Q, Fuchs CS, Meyer J, Niedzwiecki D, Zemla T, Kumthekar P, Guthrie KA, Couture F, Kuebler P, Bendell JC, Kumar P, Lewis D, Tan B, Bertagnolli M, Grothey A, Hochster HS, Goldberg RM, Venook A, Blanke C, O'Reilly EM, Shields AF. Effect of Celecoxib vs Placebo Added to Standard Adjuvant Therapy on Disease-Free Survival Among Patients With Stage III Colon Cancer: The CALGB/SWOG 80702 (Alliance) Randomized Clinical Trial. JAMA. 2021 Apr 6;325(13):1277-1286. doi: 10.1001/jama.2021.2454. PMID: 33821899; PMCID: PMC8025124. https://jamanetwork.com/journals/jama/article-abstract/2778113 リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2

にゃんごう＆いがさんのEBMerな夜 第51回放送　2021/3/26 【にゃんごう：COVID-19後遺症】 Writing Committee for the COMEBAC Study Group, Morin L, Savale L, Pham T, Colle R, Figueiredo S, Harrois A, Gasnier M, Lecoq AL, Meyrignac O, Noel N, Baudry E, Bellin MF, Beurnier A, Choucha W, Corruble E, Dortet L, Hardy-Leger I, Radiguer F, Sportouch S, Verny C, Wyplosz B, Zaidan M, Becquemont L, Montani D, Monnet X. Four-Month Clinical Status of a Cohort of Patients After Hospitalization for COVID-19. JAMA. 2021 Mar 17. doi: 10.1001/jama.2021.3331. PMID: 33729425. https://jamanetwork.com/journals/jama/fullarticle/2777787 【いがさん：NASHに対する皮下注GLP-1受容体作動薬】 Newsome PN, Buchholtz K, Cusi K, Linder M, Okanoue T, Ratziu V, Sanyal AJ, Sejling AS, Harrison SA; NN9931-4296 Investigators. A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis. N Engl J Med. 2021 Mar 25;384(12):1113-1124. doi: 10.1056/NEJMoa2028395. Epub 2020 Nov 13. PMID: 33185364. https://www.nejm.org/doi/full/10.1056/NEJMoa2028395 リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2

にゃんごう＆いがさんのEBMerな夜 第50回放送　2021/2/28 【にゃんごう：COVID-19ワクチン】 Dagan N, Barda N, Kepten E, Miron O, Perchik S, Katz MA, Hernán MA, Lipsitch M, Reis B, Balicer RD. BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting. N Engl J Med. 2021 Feb 24. doi: 10.1056/NEJMoa2101765. Epub ahead of print. PMID: 33626250. https://www.nejm.org/doi/full/10.1056/NEJMoa2101765 【いがさん：肥満に対する週1回皮下注GLP-1作動薬】 Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF; STEP 1 Study Group. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021 Feb 10. doi: 10.1056/NEJMoa2032183. Epub ahead of print. PMID: 33567185. https://www.nejm.org/doi/10.1056/NEJMoa2032183 リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2

にゃんごう＆いがさんのEBMerな夜 第49回放送　2021/1/30 ※放送中に過去2年間放送して3年目に突入と話していましたが，月1回ツイキャスで配信していたので4年間運営してきて，5年目に突入でした． 【いがさん：HPVワクチンの有害事象】 Yoon D, Lee JH, Lee H, Shin JY. ssociation between human papillomavirus vaccination and serious adverse events in South Korean adolescent girls: nationwide cohort study. BMJ. 2021 Jan 29;372:m4931. doi: 10.1136/bmj.m4931. PMID: 33514507. https://www.bmj.com/content/372/bmj.m4931 【にゃんごう：がん診療遅延】 Hanna TP, King WD, Thibodeau S, Jalink M, Paulin GA, Harvey-Jones E, O'Sullivan DE, Booth CM, Sullivan R, Aggarwal A. Mortality due to cancer treatment delay: systematic review and meta-analysis. BMJ. 2020 Nov 4;371:m4087. doi: 10.1136/bmj.m4087. PMID: 33148535; PMCID: PMC7610021. https://www.bmj.com/content/371/bmj.m4087 リスナーアンケートにご協力下さい！！ https://goo.gl/forms/5AsPilK7QnB9VrmX2