Phage Therapy Today
By Steven Yang
Each episode features accomplished guests serving various roles in developing our bacteriophage-evolved community. If you are a believer in the future shaped by phage therapy and want to share you exciting work with our community, email us at 'email@example.com'
Phage believers, hear me! Tonight, let us shake this cave.
Phage Therapy TodayNov 01, 2022
Good Manufacturing Practices (GMP) in Phage Therapy with Dr. Frenk Smrekar, founder and CEO at JAFRAL
Standardizing the phage therapy industry through processes like clinical trails is the way to go . One of the fundamental steps to broader use of phage therapy and successful therapy is producing phages following Good Manufacturing Practices (GMP) and JAFRAL is the leader in this field. In today's show we sit down with JAFRAL's founder and CEO Dr. Frenk Smrekar, a visionary who has been working on the development of GMP for bacteriophages throughout his whole career. Let's give a listen to his journey of founding the company and his observation and thought on the phage therapy field development through a GMP perspective.
Learning more about JAFRAL @https://jafral.com
A review paper on GMP in Phage Therapy by https://doi.org/10.3389/fmicb.2020.01161
The Ultimate Precision Medicine Story with tolka.ai CEO Johan Wikstroem
As a serial entrepreneur, Johan Wikstroem founded a phage therapy company recently with one goal in mind, to treat his own Mycobacteroides abscessus infection and more people with conditions like himself. Listen in to this week's "Phage Therapy Today" and find out more about how our guest transitioned from tech to biotech and overcoming the hurdles in this process.
Find out more about tolka.ai @https://tolka.ai
A Phage Therapy Cardiology Patient Case Study and Followup with Dr. Gina Suh: Director at Mayo Clinic's Phage Therapy Program
In this week's Phage Therapy Today, we get back together with Dr. Gina Suh to learn about her recent progress and experience in the application of phage therapy at Mayo Clinic. If you are interested in learning about the first case of phage therapy in treatment of a cardiology case, leading to a successful heart transplant after the clearing of heavy bacterial burden, give it a listen to today's episode! Hear out about how things are progressing in the field and where are we going next from Gina's first hand experience.
Bacteriophage Drug Development and Regulatory Affairs with Dr. Carrie-Lynn Langlais Furr, CEO and Co-founder at Bacteriophage & Drug Development Consultants (BDDC)
As more phage-based and phage-derived products and therapies emerge, swift decisions and strategies in drug development, designing clinical trials and approaching regulatory agencies come in handy. In this week's Phage Therapy Today, we sit down with Dr. Carrie-Lynn Langlais Furr, coming from a solid bacteriophage science background and coming with more than a decade's experience in phage related drug development and regulatory affairs, to talk about her advise on how to navigate these waters. Let's give it a listen to what some potential challenges lay ahead of us and how to be better prepared.
Find out more about Dr. Furr and her company Bacteriophage & Drug Development Consultants (BDDC) @https://www.linkedin.com/in/bacteriophage-and-drug-development-consultants/
The 'Citizen Phage Library' with Dr. Ben Temperton
Happy Tuesday everyone and welcome back to phage therapy today! Listen in to today's episode, we sit down with Dr. Ben Temperton, Professor at University of Exeter and founder of Citizen Phage Library. Learn about Dr. Temperton's journey and his vision for how citizen phage library can help shape the phage therapy landscape.
Let's give it a listen!
Find out more about the 'Citizen Phage Library' @https://www.citizenphage.com
Find out more about Dr. Temperton's research and work @https://tempertonlab.github.io/about/ben/
Wish you all a great thanksgiving!
Bacteriophage Engineering for Clinical and Agricultural Applications with Cytophage Technologies Inc. CEO Dr. Steven Theriault
Phage killing bacteria is cool but understanding phages and engineering their molecular biology is just another level cool. In today's 'Phage Therapy Today' podcast, we sit down with Dr. Steven Theriault, a proud Canadian, a scientist, and an entrepreneur from Cytophage Tehnologies Inc. Listen to the episode and learn about how he is building and expanding businesses in both clinical and agricultural markets across the globe, while constantly innovating on phage technologies and having fun.
You can find out more about Cytophage Technologies Inc. @https://cytophage.com
Phage Genome Annotation with Rime Bioinformatics CEO Dr. Antoine Culot
Phage genome annotation is a critical component in phage therapy to help us understand the functions of phage genes and ensure efficacy of phages. In this week's phage therapy today, we sit down with the founder and CEO at Rime Bioinformatics Dr. Antoine Culot to discuss the current challenges, regulations and opportunities in using bioinformatic tools to specifically target phage therapy needs. Let's give it a listen.....
Find out more about Rime Bioinformatics and their services @https://rime-bioinformatics.com
"The Genesis Story" and Progress in Phage Therapy with Dr. Steffanie Strathdee at UCSD IPATH
In today's show, we sit down with Dr. Steffanie Strathdee, whose family story of saving her husband's life from a life-threatening superbug infection using phage therapy really inspired a lot of the most important works today in the phage therapy field. Listen to today's episode to learn about her story. Among her many roles, as the director of the 'Center for Innovative Phage Applications and Therapeutics' at UC San Diego, Dr. Strathdee also get to help us understand the scope of power we have today in our field and much more...
Dr. Strathdee and her husband shared their story in their memoir "The Perfect Predator: A Scientists's Race to Save Her Husband from a Deadly Superbug", which can be found @ https://www.amazon.com/dp/B07H282CPT?ref=KC_GS_GB_US
Their story has also recently been spread nationwide through CNN @https://www.cnn.com/2022/07/08/health/phage-superbug-killer-life-itself-wellness/index.html
Find out more about UCSD IPATH and their resource @https://medschool.ucsd.edu/som/medicine/divisions/idgph/research/center-innovative-phage-applications-and-therapeutics/people/Pages/default.aspx
Using bacteriophages to bring back antimicrobials sensitivity in Acinetobacter baumannii with Dr. Jeremy Barr
How do bacteriophages shape bacterial fitness and how does it lead to the resensitiization of antimicrobials? In today's show, we are delighted to have Dr. Jeremy Barr from Monash University to talk about his research and his recent republication on Nature Microbiology "Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials". Maybe it's time for us to have a better understanding of the key pathogens' cellular biology and defense mechanisms to combat the challenge of AMR.
You can find the article @https://www.nature.com/articles/s41564-020-00830-7 and find out more about Dr. Barr's research @https://scholar.google.com/citations?user=Ebx3KmEAAAAJ&hl=en
Find out about Australia's collaborative effort on phage therapy @ https://phageaustralia.org
A Phage Therapy Case Study with Dr. Gina Suh: Infectious Diseases Specialist at Mayo Clinic
There have been several quite famous successful cases of using phage therapy for treatment. One of those cases was carried out at Mayo Clinic by the founder and director of Mayo Clinic’s Phage Therapy Program Dr. Gina Suh. Listen to our conversation on this story and the consideration along the process. We dig deep into how physicians are perceiving phage therapy and where we will go from there.
Check out Dr. Suh's recent publication 'Considerations for the Use of Phage Therapy in Clinical Practice' :https://pubmed.ncbi.nlm.nih.gov/35041506/
Entrepreneurship in Phage Therapy and Fighting Cholera, Poverty, Social Injustice and so much more with Dr. Minmin Yen @PhagePro
Welcome back to Phage Therapy Today and in this episode, we have Dr. Minmin Yen from PhagePro joining us to discuss her and her team's recent progress on bringing preventive phage therapy product to fight Cholera, an acute, diarrheal illness that's often associated with poverty, poor infrastructure and social injustice. Listen to her journey of bringing her research to entrepreneur execution and how our phage therapy community has been involved.
Find out more about PhagePro at: https://www.phageproinc.com/
Investment Strategies in Phage Therapy with Dr. Richard Alm at CARB-X
Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator(CARB-X) is one global nonprofit partnership that manages a large portfolio of early stage companies to do the job as described by its name. In this episode, we are happy to have its chief scientist Dr. Richard Alm to help us paint a broad picture of the antimicrobial landscape and discuss their investment strategies related to phage therapy. The global biotech is a $800B dollar market this year, with a >15% CAGR, what can we do to promote the scientific understanding of phage and phage therapy in this capital driven economy?
Find out more about CARB-X at their website: https://carb-x.org
Interacting with the FDA: A Dynamic Process, an interview with Dr. Austen Terwilliger @BMC TailorLabs
Dr. Austen Terwilliger is the director of operations at BMC TailorLabs, overseeing the cooperation between phage providers, physicians and regulatory agencies. In this conversation, we sit down and understand the dynamic nature in these processes and let's take a minute to think about how we can setup standards to better help patients.
Check out Dr. Terwilliger and BMC Tailorlab's latest work: https://www.mdpi.com/1999-4915/13/10/2049
Product Development and Product Prospects with Adaptive Phage Therapeutics CEO Greg Merril
Phage Exploration and Phage Therapy @BCM TailorLabs with Dr. Sabrina Green: Phages, from Bench to Bedside
Phage/Phage Therapy 101 with Dr. Irene Chen: All You Need to Know
Dr. Irene Chen is currently a faculty member at UCLA working on building the next generation phage therapy platform. If you are new to this field and want to catch up a bit, this is the right episode for you. On this episode, we'll talk about what phages are, what phage therapy is, what's the current state of art and much more. Besides the amazing science and technology phages are providing us, let's envision what really does phage therapy mean for our society. Yes, some of these stuff, you can learn about just from the other 10 podcast episodes on phage out there but it's simply better here.
Trailer: Introducing Phage Therapy Today
Phage therapy today is the go to podcast to learn about current achievement and progress in phage therapy. We've gathered incredible guests joining us to share their works and ideas using phage therapy to fight this antimicrobial war. We do this together, and together we can do this.